APAAN - получение МБК

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APAAN 10 (6.34 g, 39.8 mmol) was mixed with H2O (38 ml) and cooled to 0 °C in a roundbottom flask. Conc. H2SO4 was added slowly, after which the temperature was risen to150 °C under vigorous stirring. After 2h the mixture was cooled to room temperature, andthe solids were filtered and dissolved in H2O. The pH was adjusted to 5 with conc. HCl andthe solution was extracted with EtOAc, dried with MgSO4 and concentrated in vacuum togive 2.111 g of a crude P2P 5 yellow paste.

 

[Booble ᵘᵃ]

APAAN 10 (6.34 g, 39.8 mmol) was mixed with H2O (38 ml) and cooled to 0 °C in a roundbottom flask. Conc. H2SO4 was added slowly, after which the temperature was risen to150 °C under vigorous stirring. After 2h the mixture was cooled to room temperature, andthe solids were filtered and dissolved in H2O. The pH was adjusted to 5 with conc. HCl andthe solution was extracted with EtOAc, dried with MgSO4 and concentrated in vacuum togive 2.111 g of a crude P2P 5 yellow paste.

 

[YMBUkraine]

APAAN 10 (6.34 g, 39.8 mmol) was mixed with H2O (38 ml) and cooled to 0 °C in a roundbottom flask. Conc. H2SO4 was added slowly, after which the temperature was risen to150 °C under vigorous stirring. After 2h the mixture was cooled to room temperature, andthe solids were filtered and dissolved in H2O. The pH was adjusted to 5 with conc. HCl andthe solution was extracted with EtOAc, dried with MgSO4 and concentrated in vacuum togive 2.111 g of a crude P2P 5 yellow paste.

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